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KU News: KU celebrates undergraduate research at annual symposium

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From the Office of Public Affairs | http://www.news.ku.edu

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KU celebrates undergraduate research at annual symposium

LAWRENCE — More than 130 undergraduate students participated in the 27th annual Undergraduate Research Symposium earlier this month at the University of Kansas. Volunteer judges selected 28 individual presentations and three group presentations to receive Outstanding Presentation Awards. Honorees included Kansans from Atchison, Bel Aire, Kansas City, Lawrence, Olathe, Overland Park, Prairie Village, Salina, Shawnee, Topeka and Wichita.

 

Seven students receive Kansas Biological Survey Student Research Awards for 2024

LAWRENCE — The Kansas Biological Survey & Center for Ecological Research at the University of Kansas has awarded $7,500 in funding this spring for student research to be conducted this year. Seven Jayhawks will receive assistance through the research center’s 2024 Student Research Award, including Annalise Guthrie, doctoral student from Kansas City, Missouri.

Researchers parse oddity of distantly related bats in Solomon Islands that appear identical

LAWRENCE — A study of body size in leaf-nosed bats of the Solomon Islands has revealed surprising genetic diversity among nearly indistinguishable species on different islands. The research team behind the study from the University of Melbourne, Australia, included several evolutionary biologists from the University of Kansas — who collected specimens in the field, conducted genetic analysis and co-wrote the research appearing in the journal Evolution.

 

Full stories below.

 

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Contact: Erin Wolfram, Academic Success, 785-864-2308, [email protected]

KU celebrates undergraduate research at annual symposium

 

LAWRENCE — More than 130 undergraduate students participated in the 27th annual Undergraduate Research Symposium at the University of Kansas. The symposium took place online April 15-19 and featured oral and poster presentations as well as artist talks and creative displays from many disciplines. Presentations can still be viewed on the symposium website.

In addition to the previously announced ACE Talks presentation winners, who each receive $500 and have their work featured on the symposium homepage, volunteer judges selected 28 individual presentations and three group presentations to receive Outstanding Presentation Awards. Honorees each receive a $50 award per presentation.

The 2024 Outstanding Presentation Award winners are listed by name, hometown, major, link to presentation, and mentor:

Individuals

Saha Ahmadian, Olathe, biochemistry, The Effect of L-Theanine on Glycogen Phosphorylase b, mentored by Roberto De Guzman.
Josh Burton, Olathe, biochemistry, Prednisone as an Activator of Glycogen Phosphorylase b, mentored by Roberto De Guzman.
Hannah Chern, Shawnee, chemistry and molecular, cellular & developmental biology, Leveraging Zebrafish and Electrochemistry to Search for Therapies to Delay Cognitive Decline, mentored by Romana Jarosova.
Isabella Crawford-Parker, Lawrence, global & international studies and political science, Religion in the Slavic Region in Generation-Z, mentored by Brian Lagotte.
Rylee Crowell, Atchison, biochemistry, The Effect of Humalog and Lantus Insulin Injectables on Glycogen Phosphorylase B, mentored by Roberto De Guzman.
Ashley Decker, Overland Park, architecture, The Americana Circus Museum, mentored by Kapila Silva.
Eric Haberman, Bel Aire, human biology, Subcloning and Cysteine Mutagenesis of the Transmembrane Regions of the Shigella IpaB Virulence Protein, mentored by Roberto De Guzman.
Jenna Hansen, Dallas, behavioral neuroscience, Restoring Rest: The Effects of Hormone Therapy on Sleep Quality, mentored by Amber Watts.
Tae Gyu Kang, Republic of Korea, psychology, Relationship Between Characteristics of Trauma Exposure and Symptom Severity, mentored by Jeffrey Girard.
Leslie Koffi, Aurora, Colorado, architecture, Museum of Black Feminism, mentored by Kapila Silva.
Cate Manning, Omaha, Nebraska, strategic communication and global & international studies, Rhetoric v. Reality: HS2 Decision-Making, mentored by Brian Lagotte.
Priscilla Munoz, Kansas City, Missouri, pre-clinical laboratory sciences, Comparing Molecular and Morphological Diversification of Shrews (Cryptotis Parvus) between the Florida Mainland and Florida Keys, mentored by Jocelyn Colella.
Trisha Nair, Overland Park, chemistry, Investigation of the Effects of pH and Ionic Strength on AuBP1 Peptide Binding, mentored by Cindy Berrie.
Alexys Peppers, Salina, global & international studies, THAAD is Bad?, mentored by Brian Lagotte.
Janie Rainer, Overland Park, microbiology and Spanish, Identifying the YesN Regulon of Enterococcus faecalis, mentored by Lynn Hancock.
Taylor Ross, Florissant, Missouri, global & international studies, Beyond the Binary: Investigating Gender in the Olympics, mentored by Brian Lagotte.
Devin Setiawan, Indonesia, Individualized Machine-learning-based Clinical Assessment Recommendation System (iCARE), mentored by Arian Ashourvan.
Helenna Shcherbinin, Overland Park, behavioral neuroscience, Partisanship and the Distribution of Moral Foundations Across Contexts, mentored by Monica Biernat.
Olivia Sourivong, Kansas City, Kansas, social work, Intergenerational Trauma, Domestic Violence, and the Potential for Healing: A qualitative study with service providers and activists who have worked with Lao domestic violence survivors, mentored by Claire Willey-Sthapit.
David Streiler, Prairie Village, biochemistry, Effects of Dihydroxy Berberine on the Activity of Glycogen Phosphorylase B, mentored by Roberto De Guzman, and Measurement Of Intracellular Reactive Nitrogen Species in Human Microglia Using Microchip Electrophoresis and Laser Induced Fluorescence, mentored by Sue Lunte.
Mason Thieu, Topeka, exercise science, Anthropometric And Physical Fitness Profiles of Youth Athletes, mentored by Quincy Johnson.
Isabel Vanlandingham, Wichita, photography, Toyland, mentored by Elise Kirk.
Farrukhbek Varisov, Uzbekistan, theatre performance and political science, Train Tickets, mentored by Laura Kirk.
Aidan Warner, Overland Park, psychology, A Critical Analysis of Environmentalist Organizations’ Engagement with Environmental Injustice, mentored by Trevor Lies.
Emily Whisenhunt, Alexandria, Virginia, global & international studies, FIFA’s Trek to Modernity: The Role of Muslim Women in Football, mentored by Brian Lagotte.
Grace Worden, Greensboro, North Carolina, photography, No Place Like Home, mentored by Elise Kirk.
Groups

Kailyn Alani, Ellie Preston, Alyssa Lynn Rosales-Stephens, Adrian Delacruz, Shuntaro Shimakura and Isabella Wingrove, Prairie Park Nature Center Sign Project, mentored by Ali Brox and Kelly Kindscher.
Tavin Cook, Logan Littleton and Melanie Mnirajd, Evaluating the Feasibility of HLA-B *15:02 Pharmacogenomic Testing to Guide Carbamazepine Therapeutic Decisions in US Hospital, mentored by Judy Wu.
Eddie Church, Evren Dequincy, Madison Wiley, Callie Roberts, Trevor Boyd and Maggie Grandsire, EcoRadio, mentored by Kelly Kindscher.
Alyssa Marino, Aubrianna Gerdes and Elizabeth Webster, A Scoping Review of Music-Based Intervention Reporting Quality for Biological and Psychological Health Outcomes during Pregnancy in Medical Settings, mentored by Deanna Hanson-Abromeit.
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The official university account for X (formerly Twitter) is @UnivOfKansas.

Follow @KUnews for KU News Service stories, discoveries and experts.

 

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Contact: Kirsten Bosnak, KU Field Station, 785-864-6267, [email protected], @KUFieldStation

Seven students receive Kansas Biological Survey Student Research Awards for 2024

 

LAWRENCE — The Kansas Biological Survey & Center for Ecological Research at the University of Kansas has awarded $7,500 in funding this spring for student research to be conducted this year. Seven students will receive assistance through the research center’s 2024 Student Research Awards.

The students’ work covers subjects such as the impact of dry periods in microbial nitrogen processes in streams; influences on wildflower diversity in a quarter-century tallgrass prairie restoration; and planning prescribed burning using drones. During the 2024-2025 academic year, each student will present their research during one of the center’s Friday Ecology Seminars.

The Kansas Biological Survey & Center for Ecological Research houses a diverse group of ecological research and remote sensing/GIS programs. It also manages the 3,200-acre KU Field Station, a resource for study in the sciences, arts, humanities and professional schools.

“The research these students are doing is exciting, and we’re pleased to provide funding,” said Bryan Foster, who chairs the awards committee. Foster is a KU professor of ecology & evolutionary biology, a senior scientist at the research center and director of the KU Field Station.

The individual awards and their recipients are listed below. Each award is funded through KU Endowment, the independent, nonprofit organization serving as the official fundraising and fund-management organization for KU.

The Director’s Award provides support for research conducted by a graduate student. Sarah Flynn, Burlington, Kentucky, doctoral student in ecology & evolutionary biology, was awarded $1,500 in funding for her project, “How do no-flow periods impact microbial N processing in non-perennial streams?” Her adviser is Amy Burgin, professor of ecology & evolutionary biology and a senior scientist at the Kansas Biological Survey & Center for Ecological Research.

The Kenneth B. Armitage Award provides support for research conducted by an undergraduate or graduate student at the KU Field Station. Annalise Guthrie, Kansas City, Missouri, doctoral student in ecology & evolutionary biology, was awarded $1,000 in funding for her project, “Topographical controls on forest productivity as a response to climate.” Her adviser is Sharon Billings, University Distinguished Professor of Ecology & Evolutionary Biology, Dean’s Professor and a senior scientist at the Kansas Biological Survey & Center for Ecological Research.

The W. Dean Kettle Conservation Award provides support for research conducted by an undergraduate or graduate student at the KU Field Station in the area of natural resource conservation. David Weiss, Burlington, Vermont, doctoral student in geography, was awarded $1,000 in funding for his project, “Investigating the utility of NEON hyperspectral imagery for KUFS tree canopy classification.” His advisers are Jude Kastens, associate research professor at the Kansas Biological Survey & Center for Ecological Research, and Xingong Li, professor of geography & atmospheric science.

The Mari F. Pesek Award provides support for research conducted by a graduate student at the KU Field Station. Zhenghao Lin, Haining, Zhejiang Province, China, doctoral student in electrical engineering & computer science, was awarded $1,000 in funding for his project, “Safe and smart prescribed burning and planning using sUAS.” His adviser is Haiyang Chao, associate professor of aerospace engineering.

Three students received funding through the Kansas Biological Survey & Center for Ecological Research Awards, which provide support for research conducted by either undergraduate or graduate students. These students, listed below, were awarded $1,000 each.

Kayla Clouse, Farmington Hills, Michigan, doctoral student in ecology & evolutionary biology, was awarded funding for travel to give her presentation, “Maternal parent drives responsiveness to nitrogen-fixing consortium in maize.” Her adviser is Maggie Wagner, assistant professor of ecology & evolutionary biology and an assistant scientist at the Kansas Biological Survey & Center for Ecological Research.

Lydia Regier, Lincoln, Nebraska, doctoral student in ecology & evolutionary biology, was awarded funding for her project, “Increasing forb diversity in a 26-year-old tallgrass prairie restoration: the influence of disturbance, propagule addition, and fungal pathogens on community assembly.” Her adviser is Sara Baer, director of the Kansas Biological Survey & Center for Ecological Research and professor of ecology & evolutionary biology.

Yufan Zhou, doctoral student in ecology & evolutionary biology from Urumqi, Xinjiang Province, China, was awarded funding for his project, “The temporal development of plant-soil feedback in perennials and annuals.” His advisers are Maggie Wagner, assistant professor of ecology & evolutionary biology and an assistant scientist at the Kansas Biological Survey & Center for Ecological Research, and Jim Bever, Foundation Distinguished Professor of Ecology & Evolutionary Biology and a senior scientist at the Kansas Biological Survey & Center for Ecological Research.

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Don’t miss new episodes of “When Experts Attack!,”

a KU News Service podcast hosted by Kansas Public Radio.

 

https://kansaspublicradio.org/podcast/when-experts-attack

 

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Contact: Brendan Lynch, KU News Service, 785-864-8855, [email protected], @BrendanMLynch

Researchers parse oddity of distantly related bats in Solomon Islands that appear identical

 

LAWRENCE — A study of body size in leaf-nosed bats of the Solomon Islands has revealed surprising genetic diversity among nearly indistinguishable species on different islands.

The research team behind the study from the University of Melbourne, Australia, included several evolutionary biologists from the University of Kansas — who collected specimens in the field, conducted genetic analysis and co-wrote the research appearing in the journal Evolution.

“This is genus of bats called Hipposideros with multiple species all over Southeast Asia in the Pacific,” said co-author Rob Moyle, senior curator of ornithology with the KU Biodiversity Institute and Natural History Museum, whose lab conducted much of the investigation. “In the Solomon Islands, where we’ve been doing a lot of fieldwork, on each island there can be four or five different species, and they parse out in terms of body size. There’s a small, medium, large — or if there’s more than three species, there’s a small, medium, large and extra large. On one island there’s five, so there’s an extra small.”

According to Moyle, who also serves as professor of evolutionary biology at KU, previous generations of researchers reviewed the bats’ morphology, or physical traits, and concluded they’re one species.

“You go from one island to the next, and the medium-sized species is identical to the other islands,” he said. “Biologists have always looked at those and said, ‘OK, it’s obvious. There’s a small, medium and large size species distributed across multiple islands.’”

However, Moyle and his collaborators had more modern analysis at their disposal. In sequencing the DNA of bats they collected from the field (along with specimens from museum collections), the team found the large and extra large bat species weren’t actually closely related.

“That means that somehow these populations arrived at this identical body size and appearance not by being closely related — but we usually think identical-looking things are that way because they’re really closely related,” Moyle said. “It brings up questions like what’s unique about these islands that you’d have convergence of body size and appearance into really stable size classes on different islands.”

The team performed precise measurements on bats from different islands, confirming previous work by scientists in the Solomon Islands.

“All the large ones from different islands all clustered together in their measurements,” Moyle said. “It’s not just that the earlier biologists made a mistake. They looked at them and said, ‘Oh, yeah, they’re the same.’ And they’re actually not. We measured them, and they’re all clustered together, though they’re different species. We verified — sort of — that earlier morphological work.”

Moyle’s collaborators included lead author Tyrone Lavery of the University of Melbourne and KU’s Biodiversity Institute and Natural History Museum. Other KU co-authors include Devon DeRaad, doctoral student, and Lucas DeCicco, collections manager, both of the Biodiversity Institute and Natural History Museum; and Karen Olson of both KU and Rutgers University. They were joined by Piokera Holland of Ecological Solutions Solomon Islands; Jennifer Seddon of James Cook University and Luke Leung of the Rodent Testing Centre in Gatton, Australia.

Genetic analysis that revealed the bats weren’t closely related was performed at KU’s Genome Sequencing Core.

“When we created family trees using the bats’ DNA, we found that what we thought was just one species of large bat in the Solomon Islands was actually a case where bigger bats had evolved from the smaller species multiple times across different islands,” Lavery said. “We think these larger bats might be evolving to take advantage of prey that the smaller bats aren’t eating.”

DeRadd said the work could be “highly relevant” for conservation efforts in identifying evolutionarily significant units in this group.

“Body size had misled the taxonomy,” DeRadd said. “It turns out every island’s population of extra-large bats is basically genetically unique and deserving of conservation. Understanding that is really helpful. There are issues with deforestation. If we don’t know whether these populations are unique, it’s hard to know whether we should be putting effort into conserving them.”

According to DeCicco, the new understanding of leaf-nosed bats was fascinating on a purely theoretical level.

“We study evolutionary processes that lead to biodiversity,” he said. “This shows nature is more complex. We humans love to try to find patterns — and researchers love to try to find rules that apply to broad suites of organisms. It’s super cool when we find exceptions to these rules. These are patterns that you see duplicated over lots of different taxa on lots of different islands — a large and a small species, or two closely related species that differ somehow to partition their niches. We’re seeing there are lots of different evolutionary scenarios that can produce that same pattern.”

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KU News Service

1450 Jayhawk Blvd.

Lawrence KS 66045

Phone: 785-864-3256

Fax: 785-864-3339

[email protected]

http://www.news.ku.edu

 

Erinn Barcomb-Peterson, director of news and media relations, [email protected]

 

Today’s News is a free service from the Office of Public Affairs

Based on Science, Built on Trust

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As we approach the end of our 22nd season, I would like to thank our audience for trusting us to bring them health information that is current and accurate. There are many doctors out there who cannot make the same claims as the Prairie Doc’s and I would like to take this opportunity to help sort out those charlatans and quacks from trusted sources of health information.

While tasty and refreshing, I would not trust Dr. Pepper for medical advice. Nor would I trust Dr. Evil from Austin Powers, despite his claims that he went to “four years of Evil Medical School”. I like to read Dr. Seuss ’books, but I would not let him take a look. While I think he is a dear, I would not let him peek in my ear. He is not the doctor that I want to see if I needed an appendectomy.

While you can trust Doc Martin and his shoes to help you look cool, I am certain he has no medical training. Doc Brown from Back to the Future is another doctor I’m not sure I would listen to. Beside the fact that he likely has a PhD rather than an MD/DO degree, can you really trust someone who would make a time machine out of a Delorian?

“The Doctor” from Doctor Who, is someone whom his companions trust with their life. Unfortunately a sonic screwdriver will not replace a stethoscope for making a medical diagnosis. The Doctor has also been known to put those companions in grave danger from Darleks and Cybermen. Although Dr. Steven Strange from the Marvel Universe is a legitimate doctor by training, I suspect he allowed his license and board certification to lapse when he became an Avenger. Thus he would not be my first choice for current medical advice or treatment. Similarly, I would not let Doc Octo, a known villain from the Spider-Man series, use any of his mechanical arms examine me.

Dr. Benjamin Franklin Pierce, aka “Hawkeye”, from M.A.S.H. was an excellent surgeon, but his treatments and techniques are decades out of date. We have come a long way in surgery and anesthesia since the Korean War. I would also trust Dr. Quinn, Medicine Woman, but only if I was living back in the 1800’s on the prairie. The current Prairie Docs have much more training and knowledge than she had access to at the time.

As you can see, there are many doctors out there. However, when looking for medical advice, you need not only someone you can trust, but also someone who has the training to give you the most current and up to date advice. The Prairie Docs strive to answer your medical questions each week with such information. So tune in and ask anything. We are here to help you stay healthy out there, with health information that is based on science and built on over twenty years of trust.

Jill Kruse, D.O. is part of The Prairie Doc® team of physicians and currently practices as a hospitalist in Brookings, South Dakota. Follow The Prairie Doc® at www.prairiedoc.org and on Facebook and Instagram featuring On Call with the Prairie Doc®, a medical Q&A show providing health information based on science, built on trust, streaming live on Facebook most Thursdays at 7 p.m. central.

Wonderful Watermelon

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KSU horticulture

Watermelon is a warm season crop that grows well in the warm, dry days of Kansas summers. The plant grows best in deep, sandy soils; however, small icebox-type watermelons can be grown on upland shallow soils. Most watermelons require a lot of room and are not well adapted to small backyard gardens.

 

Variety considerations. There are a wide range of watermelon varieties, with many different fruit characteristics that will perform well in Kansas. Fruit shape and size, rind color, and flesh color can all be taken into consideration. Varieties with good disease resistance are also beneficial. For gardeners with small spaces, newer varieties with more compact vines have been developed.

 

Seedless watermelon. Seedless watermelons are produced by growing a specially developed cultivar that is cross-pollinated by a regular cultivar or a provided pollinator variety. Because two varieties are required to produce the seedless fruit, the amount of space needed is not practical for most home gardeners. The seedless cultivars are also less vigorous and more finicky than regular seeded watermelons.

 

When to plant. Watermelons thrive in warm soils and warm air temperatures. Plant after all danger of frost is past in early to mid-May, when soil temperature is at least 60°F and air temperatures are consistently above 70°F.

 

Spacing. Standard watermelons require about 50 square feet per plant or hill — 4 to 5 plants together, then thin to the strongest 2 plants after two true leaves have developed. Plant 4 to 5 feet apart in rows 10 to 12 feet apart. Small-vined icebox varieties can be spaced closer together, using 2 to 3 feet between hills in rows 5 to 6 feet apart. Closer spacing of large-vined, large-fruited melons will likely reduce the overall fruit size but may be a good option if garden space is limited.

 

Crop rotation. If possible in your garden space, do not plant watermelons in the same area where cucumbers, melons, squashes, or pumpkins have been planted in the past 3 to 4 years.

Care. Watermelons need a warm, sunny, well-drained growing area. If your garden soil is heavy, plant on ridges or raised beds to improve the soil drainage. Black plastic mulch can help warm the soil, conserve water, and suppress weeds in watermelon plantings. If straw mulch is used, do not apply it until the soil is warmer than 75°F.

 

Watermelons can be grown as transplants and transferred to the garden. Use a fairly large transplant or peat pot container for best results to avoid disturbing the roots when transplanting.

 

Row covers may be useful to reduce cucumber beetle damage in the early season but must be removed once the plants start flowering. Row covers can also help increase the success of transplanting due to protection from the wind. Weeds are difficult to control in sprawling vines, making early season weed control essential. Scrape weeds using shallow cultivation close to the plants.

 

Like cucumbers, cantaloupe, squash, and pumpkin, watermelons have separate male and female flowers on the same plant. Bees are necessary to transfer pollen from the male to female flowers.

 

Watermelons need plenty of water during early growth, flowering, and early fruit development. Once the melons have reached full size but have yet to ripen, watering should be minimized to encourage sweet, flavorful fruit with high sugar content.

 

Harvesting. Watermelons are ready for harvest when the underside of the fruit turns a bright buttery yellow color and when the small, curled tendril where the fruit attaches to the vine has turned brown and died. Thumping larger fruited varieties produces a dull, hollow sound when ripe; however, small icebox types are difficult to thump to determine ripeness.

 

Cowboy Code Of Conduct

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Some words on behavior from silver screen cowboys from decades ago may be more relevant and needed than ever.

The West is associated with honor, bravery, and the pioneer spirit heading into the unknown to make a better life. Today, the West continues to celebrate that “cowboy spirit” of adventure and entrepreneurial pursuits.

Principled behavior became codes of conduct that many cowboy heroes promoted in the early day Western movies and television shows. It’s not difficult to see how it wouldn’t be better following simple rules of polite and thoughtful deportment.

In a four-part series, the philosophies of four inspirational early day movie cowboys, unknown to many today, will be shared.
Singing cowboy songs, Gene Autry rode his famous horse named Champion in at least 93 movies and 91 television shows.

A world-renowned professional rodeo contractor, often entertaining at those rodeos, Autry also made worldwide public appearances. He and Champion performed at the Tri-County Fair in Herington which Grandma attended.
Autry made more than 640 recordings with 300 songs he wrote, including “Here Comes Santa Claus.”

War hero, rancher, baseball team owner, cowboy museum developer, radio, television, real estate proprietor, and comic book personality with signature cowboy toys, Autry was the most financially successful silver screen cowboy.
He’s the only entertainer to have five stars on the Hollywood Walk of Fame: radio, recording, motion pictures, television, and live performance/theater.

Gene Autry’s Cowboy Code of Honor

1. The cowboy must never shoot first, hit a smaller man, or take unfair advantage.
2. He must never go back on his word, or a trust confided in him.
3. He must always tell the truth.
4. He must be gentle with children, the elderly, and animals.
5. He must not advocate or possess racially or religiously intolerant ideas.
6. He must help people in distress.
7. He must be a good worker.
8. He must keep himself clean in thought, speech, action, and personal habits.
9. He must respect women, parents, and his nation’s laws.
10. The cowboy is a patriot.
Reminded of Matthew 7:7-11 “Ask and it will be given to you; seek and you will find; knock and the door will be opened to you. For everyone who asks receives; the one who seeks finds; and to the one who knocks, the door will be opened.”
+++ALLELUIA+++

KU News: Study reports new compound halting replication of COVID by targeting ‘Mac-1’ protein in cell models

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From the Office of Public Affairs | http://www.news.ku.edu

Headlines

Contact: Brendan Lynch, KU News Service, 785-864-8855, [email protected], @BrendanMLynch

Study reports new compound halting replication of COVID by targeting ‘Mac-1’ protein in cell models

LAWRENCE — Research appearing in the Journal of Medicinal Chemistry shows for the first time SARS-CoV-2, the virus responsible for COVID-19, can be inhibited from replicating in living cell cultures using a compound that targets “Mac-1,” a protein key to defending SARS-CoV-2 against the human immune response.

University of Kansas researchers in the lab of Anthony Fehr, associate professor of molecular biosciences at KU, teamed with scientists at the University of Oulu in Finland and McDaniel College in Maryland to test a promising molecule, called “Compound 27,” that specifically inhibits the Mac-1 protein from SARS-CoV-2.

Compound 27 was isolated via a technique called high-throughput screening and then further modified by the Finnish team to target the Mac-1 protein precisely. Then, Fehr’s KU lab tested the modified agent against the virus to gauge its effectiveness.

“Our lab really has analyzed Mac-1 in many ways over the years and laid the foundation that this is a good antiviral target,” Fehr said. “If SARS-CoV-2 doesn’t have this protein, it doesn’t cause disease in mice. So, we believe compounds targeting Mac-1 should protect people from disease.”

Compound 27 appears to be particularly effective against Mac-1. As the team reports in its new paper, “Compound 27 is the first Mac-1-targeted small molecule demonstrated to inhibit coronavirus replication in a cell model.”

“When several of the high-throughput screening hits for Mac-1 inhibitors had the same core scaffold, we realized we had discovered something really promising,” said lead author Lari Lehtiö of the University of Oulu. “Experimental crystal structures showing the detailed binding mode to Mac-1 were a key for designing new analogs, but there was also a component of luck and intuition that helped us to improve the potency of Compound 27. But — the time to actually celebrate was when we got an email from Kansas that the Mac-1 inhibitor indeed repressed SARS-CoV-2 replication.”

Fehr said therapies based on Compound 27 or similar compounds with potential to inhibit Mac-1 someday could join already existing SARS-CoV-2 medications like Remdesivir. What’s more, Mac-1-based therapies could fight emerging coronaviruses beyond SARS-CoV-2.

“There’s a distinct concern within the health and virus communities that other coronaviruses could trigger future pandemics, such as Middle East respiratory syndrome coronavirus, which is a major potential threat listed among pathogens with pandemic potential,” he said. “MERS-CoV is somewhat related but distantly compared to SARS-CoV-2. Additionally, there are various coronaviruses that cause the common cold, although they’re very distantly related to SARS-CoV-2.”

Fehr said the question arises: When will one of these viruses evolve into a deadly threat?

“We’re keen on developing coronavirus inhibitors targeting the Mac-1 across multiple coronaviruses,” he said.

An additional benefit of Mac-1 targeted approaches is that coronaviruses seem to have trouble developing adequate resistance.

“It’s a good therapeutic target, because we’re finding evidence that even if it tries to develop resistance, it’s not going to be able to do so very easily,” Fehr said. “Our evidence suggests the resistant viruses would not be able to cause disease.”

For now, Fehr is eager to move the findings into additional coronaviruses to discover if Compound 27 and other related compounds targeting Mac-1 continue to show potential.

“We’re keen to begin developing inhibitors targeting the Mac-1 across multiple coronaviruses,” he said. “Furthermore, we aim to validate these inhibitors through testing in animal models. Currently, we’re validating them in ex vivo cell cultures, but transitioning to in vivo systems would provide a more comprehensive understanding of their efficacy.”

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KU News Service

1450 Jayhawk Blvd.

Lawrence KS 66045

Phone: 785-864-3256

Fax: 785-864-3339

[email protected]

http://www.news.ku.edu

 

Erinn Barcomb-Peterson, director of news and media relations, [email protected]

 

Today’s News is a free service from the Office of Public Affairs